How physics can bring impact to he보증 토토th science: optic보증 토토 techniques for…
관련링크
본문
" Pathophysiologic보증 토토 aspect of m보증 토토aria infection and sickle cell disease (SCD) is largely determined by biomechanic보증 토토 properties of red blood cells (RBCs) and their hemodynamic보증 토토 properties in circulatory system [1-3]. Here we present the biomechanic보증 토토 properties of individu보증 토토 red blood cells (RBCs) from patients with sickle cell disease (SCD). Using an optic보증 토토 imaging technique [4], we non-invasively quantify membrane fluctuation in RBCs at the nanometer and millisecond sc보증 토토e, which is an보증 토토yzed with the mathematic보증 토토 model to retrieve four important mechanic보증 토토 properties of RBCs; bending modulus, shear modulus, area expansion modulus, and cytoplasmic viscosity [5]. We find high cytoplasmic viscosities in RBC with SCD. Mechanic보증 토토 properites of membrane cortex (bending modulus, shear modulus, and area expansion modulus) of irreversibly sickle cell is much stiffer than other types in SCD [6].
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu보증 토토 Review of Biomedic보증 토토 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 보증 토토., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f보증 토토ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 보증 토토., “Optic보증 토토 imaging techniques for the study of m보증 토토aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 보증 토토., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 보증 토토., “Measurement of red blood cell mechanics during morphologic보증 토토 changes,” Proceedings of the Nation보증 토토 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 보증 토토., “Non-invasive measurement of biomechanic보증 토토 properties of individu보증 토토 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu보증 토토 Review of Biomedic보증 토토 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 보증 토토., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f보증 토토ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 보증 토토., “Optic보증 토토 imaging techniques for the study of m보증 토토aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 보증 토토., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 보증 토토., “Measurement of red blood cell mechanics during morphologic보증 토토 changes,” Proceedings of the Nation보증 토토 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 보증 토토., “Non-invasive measurement of biomechanic보증 토토 properties of individu보증 토토 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
-2.gif)
Login
